1. | Molecular cell biology of protein folding in cells and cellular reactions due to protein misfolding | Mechanism of quality control of protein folding, action of cellular chaperones, cellular changes due to misfolded proteins, ER stress and unfolded protein response | ||
2. | Protein folding disorders and use of synthetic chaperones | Chemistry and principles of action of chemical chaperones, loss-of-function and pathological gain-of- function folding disorders, correction of Fabry disease by a pharmacological chaperone, correction of open-angle glaucoma by a chemical chaperone |